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Metformin: A diabetes drug with anti-aging potential Metformin is a widely prescribed medication for type-2 diabetes, first synthesized in 1922 and FDA-approved in 1994 (72 years later!)
Sin embargo, con el tiempo, la CBP pierde la capacidad de generar hiperinsulinemia compensatoria y se produce dficit de insulina, lo que conlleva a la prdida de la regulacin de la glucosa y a la hiperglucemia sostenida, que genera glucotoxicidad y lipotoxicidad, conllevando a la disfuncin y muerte de la CBP, lo cual denota un importante ciclo vicioso 41
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Any of these protocols should be clinician-directed, with baseline labs, a compliant compounding pharmacy, and a clear plan for how youll evaluate response at the 3-month mark
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